What body of water separates the West Indies from South America?

The body of water that separates the West Indies from South America is the Caribbean Sea.

The Caribbean Sea is located to the east of Central America and to the north of South America, forming a distinct boundary between these regions and the island nations of the West Indies. This sea plays a crucial role in the climate and trade of the region. If you have more questions or need further clarification, feel free to ask!